Table 1. Column 1 lists the top-16 cis–trans interacting transcripts; column 2 shows the number of tested cis-SNPs for each transcript; column 3 shows the number of cis-trans tests; column 4 list shows the Bonferroni-adjusted P-values necessary for a ‘significant' finding; column 5 shows the uncorrected P-value per transcript obtained in the two-locus interaction analysis; the next columns provide information about the cis- and trans-SNPs including their eQTL effects under a one-locus model.
| No. of | No. of | Top cis-acting SNP | Top trans-acting SNP | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcripta | tested cis-SNPs | epistasis tests | Bonferroni P-value | Top two-locus P-value | rs | Chr | Position | One-locus P-value | rs | Chr | Position | One-locus P-value | RefSeq genes |
| TRIM4 | 9 | 779 436 | 6.41E-08 | 2.82E-12 | rs1121592 | 7 | 99 361 567 | 2.40E-06 | rs457414 | 3 | 10 177 884 | 1.47E-01 | VHL, IRAK2 |
| PNPLA6 | 77 | 6 663 272 | 7.50E-09 | 5.99E-12 | rs608773 | 19 | 7 743 306 | 8.73E-01 | rs1794066 | 2 | 113 602 821 | 7.19E-01 | IL1RN |
| ARNT | 27 | 2 337 822 | 2.14E-08 | 8.26E-12 | rs7532008 | 1 | 149 226 974 | 8.68E-01 | rs2937504 | 5 | 11 015 227 | 5.14E-01 | CTNND2, DAP |
| MANBA | 51 | 4 414 662 | 1.13E-08 | 1.70E-11 | rs4698863 | 4 | 1 03 764 896 | 1.81E-04 | rs13171027 | 5 | 4 031 902 | 5.97E-01 | IRX1 |
| PHF11 | 46 | 3 982 082 | 1.26E-08 | 2.08E-11 | rs2181539 | 13 | 48 569 216 | 6.52E-01 | rs7571794 | 2 | 67 969 620 | 7.46E-01 | ETAA1 |
| C17orf70 | 47 | 4 068 602 | 1.23E-08 | 5.10E-11 | rs7207933 | 17 | 77 131 682 | 3.75E-07 | rs35060330 | 5 | 150 818 278 | 8.38E-01 | SLC36A1 |
| UEVLD | 58 | 5 020 190 | 9.96E-09 | 5.66E-11 | rs6483561 | 11 | 18 966 071 | 7.05E-01 | rs5743404 | 8 | 6 724 531 | 4.68E-01 | DEFB1 |
| GMDS | 138 | 11 933 550 | 4.19E-09 | 6.06E-11 | rs932409 | 6 | 1 396 521 | 6.63E-01 | rs2143980 | 14 | 32 277 657 | 3.21E-01 | AKAP6 |
| CCDC28A | 65 | 5 625 620 | 8.89E-09 | 6.74E-11 | rs12190319 | 6 | 138 316 778 | 2.29E-01 | rs1391285 | 1 | 215 628 091 | 4.90E-01 | ESRRG, GPATCH2 |
| UBTD2 | 92 | 7 959 932 | 6.28E-09 | 6.76E-11 | rs17074786 | 5 | 171 791 185 | 3.32E-01 | rs4776794 | 15 | 64 659 320 | 8.57E-02 | LCTL, SMAD6 |
| RNF40 | 15 | 1 298 970 | 3.85E-08 | 6.77E-11 | rs4788213 | 16 | 29 942 025 | 1.23E-01 | rs638286 | 19 | 55 397 668 | 2.20E-01 | MYH14 |
| CCDC88C | 83 | 7 181 990 | 6.96E-09 | 7.26E-11 | rs2430363 | 14 | 91 434 804 | 2.78E-01 | rs2748992 | 6 | 52 704 534 | 3.12E-01 | — |
| GEMIN5 | 98 | 8 478 470 | 5.90E-09 | 7.35E-11 | rs7732085 | 5 | 153 693 955 | 2.72E-01 | rs1562797 | 16 | 52 900 570 | 4.55E-01 | IRX3 |
| EZH2 | 85 | 7 354 880 | 6.80E-09 | 7.82E-11 | rs851704 | 7 | 147 169 364 | 3.97E-01 | rs1957190 | 14 | 45 567 885 | 5.58E-01 | RPL10L |
| TGDS | 70 | 6 058 010 | 8.25E-09 | 9.00E-11 | rs7993213 | 13 | 94 886 853 | 6.40E-01 | rs13392004 | 2 | 48 495 333 | 2.92E-01 | FOXN2, CCDC128 |
| CEBPZ | 87 | 7 527 762 | 6.64E-09 | 9.16E-11 | rs12052952 | 2 | 36 842 683 | 4.59E-02 | rs807018 | 10 | 102 763 001 | 5.41E-01 | PDZD7 |
a
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