TABLE 1.

Parameter values for [CSL]- and [CaM]-dependent activity of the Cav1.2 channel

Data shown in Fig. 2 were fitted by Equations 2–4 using DeltaGraph software. To reduce the number of variables in the curve fitting, values of K_dl, nl, and nf obtained in the fittings of CSL data and CaM data were used as fixed values in other curve fittings (marked with asterisks). The partial agonist efficacy (α) was calculated from a ratio of the effects of CSL (A_max) on CaM (A_max·α) as 0.14 and treated as a fixed value in further analysis. For further explanation, see “Experimental Procedures.”

Test solution	Amax	Kdl	nl	Kdf	nf	Kdi	ni
	%	μm		μm		μm
CSL	177	0.7	1.6
CSL with 1.22 μm CaM	130	0.7*	1.6*	0.3	1.4*	7.4	3.7
CaM	177			0.5	1.4	6.4	3.0
CaM with 10 μm CSL	211	0.7*	1.6*	0.5	1.4*	6.4	2.8