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. 2011 Sep 9;286(45):39387–39402. doi: 10.1074/jbc.M111.279893

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Relation of HO-1 expression with gastric mucosal injury at different times after administration of indomethacin. A, hematoxylin and eosin staining of gastric mucosal section. Histological evidence for induction of mucosal injury and subsequent healing with time after indomethacin treatment is shown. The arrow indicates severe mucosal damage at 4 and 12 h after indomethacin treatment. B, the expression of HO-1 mRNA upon induction of injury by indomethacin at different time points as followed by RT-PCR together with the densitometric analysis of RT-PCR data. Actin was used as an internal control. C, measurement of HO-1 activity. Gastric mucosal total homogenate was used to measure HO-1 activity in vivo by following the formation of bilirubin as described under “Experimental Procedures.” 0 h represents control. Data are presented as mean ± S.E. (***, p < 0.001 versus control; **, p < 0.05 versus control; n = 6).