TABLE 2.

Parameters simulating the c[NO] distributions recorded by detector cells

Region	Maximum source surface-to-detector cell separation	NO concentration at source surface	NO emission rate at source surface	Tissue NO source strengtha	Half-maximum NO synthase enzyme activityb
	μm	nm	nmol m−2s−1	nm s−1	nm s−1
Cerebellum					158 (whole cerebellum)
IGLc	9.5	1.4	1.0	353 (3.1 nm)
ML/PCL	9.0	0.57	0.41	160 (1.2 nm)
EGL	8.0	0.12	0.088	36 (0.25 nm)
Hippocampus (CA1)	7.0	1.4	1.0	353 (3.1 nm)	139 (whole hippocampus)

^a Tissue NO generation rates giving the concentrations at the source surface (third column). Values in parentheses are the predicted steady-state NO concentrations within the tissue. See supplemental Methods for details of the calculations.

^b From assays on homogenized adult rat cerebellum and hippocampus (51), assuming 1 ml/g wet weight and age corrections from data on rat cerebellum and forebrain, respectively (52).

^c IGL, internal granule cell layer; EGL, external granule cell layer; ML/PCL, molecular/Purkinje cell layer.