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. 2011 Oct 18;286(50):42808–42817. doi: 10.1074/jbc.M111.310169

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Ceramide 1-phosphate directly and specifically interacts with TACE. A, representative sensorgrams for 1 μm WT TACE injected over an active surface of either C_18:1/16:0 C1P (C16 C1P), C_18:1/2:0 C1P (C2 C1P), dioleoyl-PA (PA), S1P, or C_18:1/16:0 ceramide (C16 Cer) subtracting the POPC/POPE control surface. B, data were collected in triplicate and averaged as shown by the bar graphs for C_18:1/16:0 C1P (C16 C1P), dioleoyl-PA (PA), S1P, or C_18:1/16:0 ceramide (C16 Cer). Error bars represent the standard deviation from each of the independent trials. A Student's t test was employed to assess the statistical significance of the results (*, p < 0.05). ns = not significant. C, chain length specificity of TACE was investigated for C_18:1/8:0 (C8), C_18:1/16:0 (C16), and C_18:1/18:1 (C18:1) C1P using SPR as in A and B.