FIGURE 1.

SelK and SelS form a novel SelS/SelK family of proteins. A, schematic representation of domain organization of SelK and SelS proteins. B, criteria for the identification of eukaryotic proteins belonging to the SelS/SelK family. C, multiple alignment of a novel member of the SelK/SelS family, Romo1. The following elements of domain structure are marked: transmembrane region (TM); a region rich in glycine, proline, and positively charged amino acids (G-rich); and a coiled-coil domain (Coiled-coil) of SelS. The locations of Sec or Cys residues are shown in bold type.