TABLE 1.
Microbicidal activity of TC-1 and TC-derived peptides
Peptides were named after the first residue and its position in TC-1. RA indicates reduced/alkylated.
| Peptide | Sequence | Charge | LC99.9 |
|||
|---|---|---|---|---|---|---|
| B. subtilis | E. coli | S. aureus | C. neoformans | |||
| μm | ||||||
| rTC-1 | AELRCMC… . LAGDES | +4 | 3.8 | 1.9 | 1.9–3.8 | 7.5 |
| RA rTC-1 | AELRCMC… . LAGDES | +4 | 3.8 | 3.8 | 1.9–3.8 | 15 |
| rTC-1a | AELRCMC… . LAGDES | +4 | >60 | >60 | >60 | >60 |
| RA rTC-1a | AELRCMC… . LAGDES | +4 | >60 | >60 | >60 | >60 |
| A1 | AELRCMCIKTTSGIH | +1 | 15 | 30 | >120 | 15 |
| E2 | ELRCMCIKTTSGIHP | +1 | 30 | 60 | >120 | 7.5 |
| L3 | LRCMCIKTTSGIHPK | +3 | 3.8 | 7.5 | 30 | 1.9 |
| R4 | RCMCIKTTSGIHPKN | +3 | 15 | 7.5 | >120 | 3.8 |
| C5 | CMCIKTTSGIHPKNI | +2 | 60 | >120 | >120 | 60 |
| M6 | MCIKTTSGIHPKNIQ | +2 | >120 | >120 | >120 | >120 |
| D51 | DAPRIKKIVQKKLAG | +4 | 30 | 120 | >120 | 30 |
| A52 | APRIKKIVQKKLAGD | +4 | 30 | >120 | 120 | 30 |
| P53 | PRIKKIVQKKLAGDE | +3 | 120 | >120 | >120 | 60–120 |
| R54 | RIKKIVQKKLAGDES | +3 | 60–120 | >120 | >120 | 30 |
a Testing was done with 0.9% NaCl.