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Inhibition constants of Aldi inhibitors for human ALDH isoenzymes
| Inhibitor | Average IC50 values (μm) |
||
|---|---|---|---|
| ALDH1A1 | ALDH2 | ALDH3A1 | |
| Aldi-1 | 2.2 (0.3)a | 8.6 (1.2) | 12 (1.0) |
| Aldi-2 | 2.5 (0.1) | 6.4 (1.0) | 1.9 (0.1) |
| Aldi-3 | 7.9 (0.4) | 5.4 (1.3) | 1.7 (0.1) |
| Aldi-4 | 6.8 (0.3) | 8.3 (1.2) | 2.2 (0.3) |
| Ki (m−1 s−1) | |||
| Aldi-1 | NDb | 240 | 30 |
a Values in parentheses are S.D. for three independent assays.
b ND, not determined.
