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. 2011 Oct 5;286(50):43429–43436. doi: 10.1074/jbc.M111.299339

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Histone modifications of the IL2 gene in response to T lymphocyte activation and in SLE T cells. A, activation of naïve CD4⁺ T lymphocytes with anti-CD3 and anti-CD28 antibodies results in increased histone H3K18 acetylation and decreased histone H3K27 trimethylation. Results are displayed as relative increase in histone H3K18 acetylation and H3K27 trimethylation based on the situation in naïve CD4⁺ T lymphocytes (indicated by dashed line = 100%). B, T lymphocytes from SLE patients display decreased histone H3K18 acetylation and increased histone H3K27 trimethylation compared with T lymphocytes from healthy controls. Results are displayed as relative histone H3K18 acetylation and H3K27 trimethylation based on the situation in control T lymphocytes (indicated by dashed line = 100%). Error bars, S.D.