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. 2011 Oct 5;286(50):43429–43436. doi: 10.1074/jbc.M111.299339

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — DNMT3a interacts with CREMα and gets recruited to IL2 −180 CRE. A, upper, CREMα and DNMT3a were transfected into HEK293T cells as indicated, and overexpression is shown by immunoblotting of cell lysates. Lower, co-immunoprecipitated (IP) DNMT3a is shown. Both endogenous CREMα (fourth lane 4) and overexpressed CREMα protein (sixth lane) co-immunoprecipitate overexpressed DNMT3a protein. B, SLE T cells that produce significantly less IL-2 compared with controls show increased DNMT3a recruitment to the IL2 −180 CRE site compared with control T lymphocytes. Corresponding results from age-, gender-, and ethnicity-matched controls are connected to data from SLE T cells by dashed lines.