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. 2011 Oct 25;286(50):43054–43061. doi: 10.1074/jbc.M111.273474

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Trans-Acting effects of CD deletion mutants on ΔPD secretion. HEK293T cells were cotransfected with ΔPD and PCSK9 mutants with deletions in CD. Protein was detected with anti-His tag (HT) and anti-PCSK9 antibodies for PCSK9 and its mutants in cell lysates and in the conditioned medium, with the anti-LDLR antibody for LDLR levels in the total cell lysates, and with the anti-β-actin antibody as a protein loading control. Quantitative analysis of the cellular LDLR levels is shown in supplemental Fig. 2B.