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Discrete CD protein inhibits PCSK9 function in vitro and in vivo. A, HepG2 cells were treated with purified PCSK9 and increasing amounts of ΔCD or CD. Cell membrane LDLR levels were measured by Western blotting. B, full-length PCSK9 (FL; 20 μg/mouse) and the discrete CD protein (40 μg/mouse) separately or in combination were injected into C57BL/6 mice (n = 3 for each group). Plasma cholesterol levels were followed for 4 h. *, p < 0.01.
