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. Author manuscript; available in PMC: 2012 Nov 29.
Published in final edited form as: Biochemistry. 2011 Nov 2;50(47):10203–10214. doi: 10.1021/bi200964p

Figure 9.

Figure 9

Topological model of the CF I complex. In this model, the Rna14 dimer interacts in an asymmetric manner with Pcf11, and both copies of Rna15 interact with the pre-mRNA (dotted line). Both copies of Rna15 are tethered to the complex via the flexible region of Rna14 that separates the structured HAT repeats (large red ovals) from the monkeytail domain at the C-terminus that interacts with Rna15 (smaller red ovals behind Rna15). One of the Rna15 subunits makes additional interactions with Pcf11 and Hrp1. We do not know which of the two Rna15 subunits interacts with Pcf11. Clp1 is shown binding Pcf11, but not other subunits.