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. 2011 Aug 21;286(49):42534–42544. doi: 10.1074/jbc.M111.242412

FIGURE 8.

FIGURE 8.

Model for the impairment of autophagy by palmitate. By suppressing mitochondrial bioenergetics, palmitate impairs cellular ATP levels, thus decreasing the lysosomal H+ pump capacity to acidify its lumen, a process required for hydrolase activity and for the fusion of the AP with the lysosome.