FIGURE 5.

Curcumin reverted drug resistance and provided survival advantage of doxorubicin-treated tumor-bearing mice. a, doxorubicin-sensitive/resistant tumor-bearing mice were treated with doxorubicin alone or in combination with curcumin at different doses, and the total number of viable tumor cells in the peritoneal cavity was assayed by trypan blue dye-exclusion test. b, doxorubicin-resistant tumor-bearing mice were treated with doxorubicin alone or in combination with curcumin, and the tumor cells were subjected to flow cytometric determination of percentage hypoploidy (sub-G₀/G₁ phase cells). c, the survival rates of doxorubicin-resistant tumor-bearing animals treated with doxorubicin alone or in combination with curcumin were calculated by counting the number of live animals at a fixed time interval and were represented as Kaplan-Meier curve. Values are the mean ± S.E. of five independent experiments in each case. *, p < 0.05 when compared with respective control sets.