FIGURE 2.

AMI sensitizes ASIC3 channels under mild acidosis. AMI at low micromolar concentrations (1–300 μm) sensitizes the response to mild acidosis (A, pH 7.2; B, pH 7.0; and C, pH 6.8) but not to a more extreme acidosis (D, pH 6.5). Upper panels show representative current traces at −60 mV, and lower panels are means ± S.E. of four to seven measurements normalized to the currents induced by acidosis alone (control; dashed line). *, p < 0.05; **, p < 0.001 versus controls.