TABLE 2.
Changes in phospholipids in heart from mice with diet-induced obesity
Values shown are means ± S.E.
| Lipid classes (mg/mg tissue) | Chow |
HFD |
||
|---|---|---|---|---|
| Cbs+/+ (n = 4–5) | Cbs+/− (n = 5) | Cbs+/+ (n = 6) | Cbs+/− (n = 5–6) | |
| Phosphatidylcholine | 9.88 ± 0.29 | 12.04 ± 1.63 | 9.87 ± 0.14 | 11.28 ± 1.42 |
| Phosphatidylethanolamine | 6.04 ± 0.38 | 7.10 ± 0.85 | 7.63 ± 0.12 | 7.73 ± 1.16 |
| Phosphatidylinositol | 1.14 ± 0.04 | 1.46 ± 0.22a | 1.13 ± 0.02 | 1.48 ± 0.16a |
| Phosphatidylserine | 1.04 ± 0.07 | 1.56 ± 0.31a | 0.87 ± 0.06 | 1.45 ± 0.29a |
| Lysophosphatidylcholine | 2.42 ± 0.13 | 4.28 ± 1.34a | 1.93 ± 0.11 | 3.73 ± 0.95a |
| Sphingosine | 0.98 ± 0.05 | 1.36 ± 0.27a | 0.80 ± 0.04 | 1.35 ± 0.23a |
| Cardiolipin | 3.54 ± 0.16 | 4.54 ± 0.68 | 3.63 ± 0.11 | 3.95 ± 0.63 |
a p < 0.05 versus Cbs+/+ mice, as determined by two-way analysis of variance.