TABLE 1.

Influence of herbimycin A or imatinib on the capacity of the catalytic TK domains of SmTK3, SmTK6, or SmAbl1 expressed in Xenopus oocytes to induce GVBD

SmTK3-TK-induced GVBD (numbers represent % GVBD; mean of two independent experiments) was completely blocked by herbimycin A at a concentration of 0.01 μm. Total inhibition of SmTK6-TK-induced GVBD required 10 μm. At this concentration, SmAbl1-TK was still active (60%). − = not determined.

Herbimycin A	0.0001 μm	0.001 μm	0.01 μm	0.1 μm	1 μm	10 μm	Control
SmTK3-TK	100	80	0	0	0	0	100
SmTK6-TK	−	−	100	100	88	0	100
SmAbl1-TK	−	−	−	100	80	60	100