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. Author manuscript; available in PMC: 2011 Dec 9.
Published in final edited form as: J Med Genet. 2010 Nov 19;48(3):168–176. doi: 10.1136/jmg.2010.083022

Figure 3.

Figure 3

Skin cancer and mortality in XP patients. A. Probability of the absence of skin cancers for all XP patients (n=106). At age 12 years, 50% of the patients had been diagnosed with NMSC or melanoma skin cancer (arrows) B. Scatter plot age of diagnosis of first skin cancer in patients with both NMSC and melanoma. NMSC was diagnosed earlier or at the same time as melanoma in 29/31 patients.. C. Probability of the absence of skin cancer stratified by burning phenotype. Patients that “never” burned on minimal sun exposure (n= 38) were significantly more likely to develop NMSC or melanoma skin cancer at an earlier age than those that “always or sometimes” burned (n=65) on minimal sun exposure (p=0.006). D. Probability of the absence of skin cancer stratified by XP complementation group. Patients in complementation groups XP-A, XP-B, XP-D and XP-G developed skin cancer at a significantly older age than those in complementation groups XP-C, XP-E and variant (p=0.009). E. Kaplan Meier curve of xeroderma pigmentosum patient survival compared to US general population. 30% of XP patients had died by age 32. The survival of the XP patients was significantly less than the general population (p<0.001). F. Kaplan Meier curve of xeroderma pigmentosum patient survival stratified by neurologic phenotype. Patients with neurologic degeneration had poorer survival rates than those without neurologic degeneration (p=0.04).