Table 1.
Common significant transcripts across all tissues with >30% change (LogR > 0.1 in any tissue) after the direct comparison between LRRK2 G2019S and KO (two-way ANOVA P < 0.001)
| Accession number | Gene symbol | Gene name | LogR LRRK2 G2019S/KO |
Cross tissue average | |||
|---|---|---|---|---|---|---|---|
| Striatum | Cortex | Kidney | Muscle | ||||
| NM_011164 | Prl | Prolactin | 1.99 | 0.94 | 0.02 | 0.00 | 0.74 |
| NM_008117 | Gh | Growth hormone | 1.9 | 1.42 | −0.01 | 0.05 | 0.84 |
| NM_008045 | Fshb | Follicle-stimulating hormone beta | 0.61 | 0.17 | −0.08 | 0.03 | 0.18 |
| AK014938 | Lrrk2 | Leucine-rich repeat kinase 2 | 0.45 | 0.49 | 0.58 | 0.71 | 0.56 |
| NM_001039677 | Slc30a2 | Solute carrier family 30 (zinc transporter), member 2 | 0.16 | 0.1 | −0.02 | 0.15 | 0.1 |
| CA751126 | Abcf2 | ATP-binding cassette, subfamily F (GCN20), member 2 | −0.12 | −0.08 | 0.01 | −0.02 | −0.05 |
| BY344923 | Tbc1d7 | TBC1 domain family, member 7 | −0.16 | −0.28 | 0.03 | 0.01 | −0.1 |
| BC117876 | Zfp287 | Zinc finger protein 287 | −0.25 | −0.29 | −0.09 | −0.16 | −0.2 |
| NM_001039094 | Negr1 | Neuronal growth regulator 1 | −0.27 | −0.17 | −0.04 | −0.24 | −0.18 |
| AK018644 | n/a | Hypotheticala | −0.33 | −0.5 | −0.14 | −0.14 | −0.28 |
| NM_198607 | 4930572J05Rik | RIKEN cDNA 4930572J05 gene | −0.35 | −0.21 | −0.13 | −0.09 | −0.2 |
aMicrobodies C-terminal targeting signal/phenylalanine-rich region containing protein.