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. 2011 Oct 4;21(1):219–235. doi: 10.1093/hmg/ddr456

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© The Author 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Summary of bisulfite sequencing results. (A) Three X-linked loci (CXHs15, CXHs13 and CXHs6) and (B) three autosomal loci (C2Hs, C11Hs and C20Hs) in Turner (45,X), male (46,XY), female (46,XX), Klinefelter (47,XXY) samples and one Klinefelter sample with a 49,XXXXY karyotype. Equal amounts of DNA from three individuals were pooled together prior to bisulfite treatment, PCR products were cloned into a TA cloning vector and large numbers of individual clones were sequenced. Individual CpGs are represented as blue filled and yellow filled circles representing methylated and unmethylated CpGs, respectively. Average methylation of all CpGs in all sequenced clones in a given region is provided under each group of clones. Vertical arrows indicate the positions of the CpGs studied by SIRPH or pyrosequencing reaction.

Figure 4. — Summary of bisulfite sequencing results. (A) Three X-linked loci (CXHs15, CXHs13 and CXHs6) and (B) three autosomal loci (C2Hs, C11Hs and C20Hs) in Turner (45,X), male (46,XY), female (46,XX), Klinefelter (47,XXY) samples and one Klinefelter sample with a 49,XXXXY karyotype. Equal amounts of DNA from three individuals were pooled together prior to bisulfite treatment, PCR products were cloned into a TA cloning vector and large numbers of individual clones were sequenced. Individual CpGs are represented as blue filled and yellow filled circles representing methylated and unmethylated CpGs, respectively. Average methylation of all CpGs in all sequenced clones in a given region is provided under each group of clones. Vertical arrows indicate the positions of the CpGs studied by SIRPH or pyrosequencing reaction.