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a. The N loop of CXCL8 (blue) binds to CXCR1 in site 1, which includes the N-terminus of CXCR1 (blue), the major determinant for the selective high affinity binding to CXCL8. Site 2 in CXCR1 binds Glu4 (sphere) of CXCL8 to trigger receptor activation. b. CXCR2 binds to the N-terminus of CXCL8 (Glu4, Arg6 and CXC are represented as spheres) to elicit receptor activation.
