Table 1. Codon bias and codon pair bias scores for FPR1 variants calculated based on the codons for ten validated SNPs.
| FPR1 haplotype | Amino acid number | Codon bias | Codon pair bias | |||||||||
| 11 | 47 | 101 | 102 | 116 | 182 | 190 | 192 | 331 | 356 | |||
| 1A | T | V | V | F-t | I-c | P-c | R | K | T-c | A | 189.9 | −0.900 |
| 1C | T | V | V | F-t | I-c | P-c | R | K | T-t | A | 184.1 | −1.107 |
| 2A | T | V | V | F-t | I-c | P-c | W | N-c | T-c | A | 178.3 | −1.854 |
| 3A | I | V | V | F-t | I-c | P-c | R | N-t | T-c | E | 209.1 | +0.443 |
| 3C | I | V | V | F-t | I-t | P-a | R | N-t | T-c | E | 201.4 | −0.783 |
| 4A | I | V | L | F-t | I-c | P-c | R | N-t | T-c | A | 182.0 | +1.085 |
| 5A | T | V | L | F-t | I-c | P-c | R | K | T-c | A | 195.0 | +0.471 |
| 6A | T | V | L | F-t | I-c | P-c | R | N-t | T-c | A | 180.1 | +0.932 |
| 8A | I | V | V | F-t | I-c | P-c | R | N-t | T-c | A | 174.0 | −1.765 |
| 9A | I | V | V | F-t | I-c | P-c | R | K | T-c | A | 191.8 | −0.747 |
| 10A | I | V | L | F-t | I-c | P-c | R | K | T-c | A | 196.5 | +0.625 |
| 11A | T | V | V | F-t | I-c | P-a | R | N-t | T-c | A | 172.1 | −1.918 |
| 12B | T | V | V | F-t | I-c | P-c | R | N-t | T-c | E | 207.2 | +0.380 |
| 12C | T | V | V | F-t | I-c | P-a | R | N-t | T-c | E | 204.3 | −1.098 |
| 12D | T | V | V | F-c | I-c | P-c | R | N-t | T-c | E | 209.9 | +2.346 |
| 16A | T | V | V | F-c | I-c | P-c | R | K | T-c | E | 224.8 | +1.796 |
| 25A | T | A | L | F-t | I-c | P-c | R | K | T-c | E | 227.2 | +1.202 |
Haplotype designations 1A-16A are by Sahagun-Ruiz et al. [2]. B, C and D show haplotypes in which the SNP does not change the amino acid compared to A [4]. The table includes the FPR1 SNPs in the following order: c.32C>T/p.T11I, c.140T>C/p.V47A, c.301G>C/p.V101L, c.306T>C/p.F102F, c.348C>T/p.I116I, c.546C>A/p.P182P, c.568A>T/p.R190W, c.576T>G>C/p.N192K, c.993C>T/p.T331T, c.1037C>A/p.A356E. The codon bias results show the differences between the various haplotypes based on the total of each SNP codon usage score, as obtained from the GenBank Homo sapiens Codon Usage Database (http://www.kazusa.or.jp/codon/cgi-bin/showcodon.cgi?species=9606). The codon pair bias results show the differences between the various haplotypes based on the total of each SNP codon pair score, as calculated from the Supplemental Material by Coleman et al. www.sciencemag.org/cgi/content/full/320/5884/1784/DC1 [6]. Amino acids are shown in single letter code. The nucleotide in the 3rd position of the synonymous codons is as shown.