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. 2011 Dec 9;6(12):e28938. doi: 10.1371/journal.pone.0028938

Figure 3. Time courses for 6 CSF neurodegeneration biomarkers in relation to functional outcome and the severity of cerebral vasospasm.

Figure 3

Long-term outcome was dichotomized to either poor (closed circles: GOS-E  = 1–4; mRS  = 4–6) or good (open boxes: GOS-E  = 5–8; mRS  = 1–3), while angiographic vasospasm was categorized as either moderate/severe (closed circles) or absent/mild (open boxes) as described in Methods. Mean CSF levels of each neurodegeneration biomarker at the indicated times post-aneurysm rupture (in days) are shown with the standard error of the mean. Statistically significant between-group differences (p<0.05) are identified by asterisk. In cases for which CSF samples were available at both 7 and 10 days post-rupture, the higher marker level was considered.