Table 2.

Calendar period hazard rate ratios and 95% confidence intervals for death derived from Cox proportional hazards models, adult glioblastoma multiforme cases, SEER, 1993–2007

	Univariate HR (95% CI)	Multivariate-adjusted HRa (95% CI)
Age (years):	20+	20+	20–44	45–64	65–79	80+	20–69
Deaths/cases:	17,110/19,674	17,110/19,674	1,682/2,219	7,561/8,976	6,497/7,049	1,370/1,430	11,487/13,695
Period
1993–1995	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
1996–1998	0.99 (0.94–1.05)	0.97 (0.92–1.03)	0.95 (0.80–1.12)	0.96 (0.88–1.05)	0.99 (0.90–1.08)	1.00 (0.79–1.26)	0.97 (0.90–1.04)
1999–2001	0.91 (0.87–0.96)	0.89 (0.85–0.94)	0.82 (0.70–0.95)	0.87 (0.81–0.94)	0.91 (0.83–0.98)	1.10 (0.90–1.35)	0.87 (0.82–0.92)
2002–2004	0.82 (0.78–0.86)	0.78 (0.74–0.82)	0.77 (0.66–0.90)	0.75 (0.69–0.81)	0.80 (0.74–0.87)	0.96 (0.79–1.18)	0.75 (0.71–0.80)
2005–2007	0.72 (0.68–0.76)	0.69 (0.65–0.72)	0.66 (0.55–0.79)	0.63 (0.58–0.69)	0.70 (0.64–0.76)	1.05 (0.86–1.29)	0.64 (0.60–0.68)
p-value for period effect	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	0.48	<0.0001

HR, hazard ratio; CI, confidence interval

^aAdjusted for sex, age, race/ethnicity, and marital status