Table 4.
Two-year and median survival by calendar period, adult glioblastoma multiforme cases, SEER, 1993–2007
| Age (years): | 20+ | 20–44 | 45–64 | 65–79 | 80+ | 20–69 |
|---|---|---|---|---|---|---|
| Survival statistics by period | ||||||
| All cases | ||||||
| 2-year survival, percenta (95% CI) | ||||||
| 1993–1995 | 7 (6, 8) | 24 (20, 29) | 7 (5, 9) | 1 (1, 2) | 1 (0, 4) | 9 (7, 10) |
| 1996–1998 | 7 (6, 9) | 25 (21, 30) | 8 (7, 10) | 2 (1, 3) | 1 (0, 4) | 10 (9, 12) |
| 1999–2001 | 9 (9, 10) | 33 (28, 37) | 10 (9, 12) | 2 (2, 3) | 1 (0, 2) | 13 (12, 14) |
| 2002–2004 | 13 (12, 14) | 35 (31, 39) | 16 (14, 17) | 5 (4, 6) | 2 (1, 3) | 18 (16, 19) |
| 2005–2007 | 17 (16, 19) | 39 (33, 44) | 21 (19, 24) | 9 (7, 11) | 1 (0, 4) | 22 (21, 24) |
| Median survival, monthsb (95% CI) | ||||||
| 1993–1995 | 7.5 (7.5, 7.5) | 13.5 (12.5, 15.5) | 9.5 (8.5, 9.5) | 5.5 (4.5, 5.5) | 3.5 (2.5, 4.5) | 9.5 (8.5, 9.5) |
| 1996–1998 | 7.5 (7.5, 7.5) | 15.5 (14.5, 16.5) | 9.5 (9.5, 10.5) | 5.5 (4.5, 5.5) | 3.5 (3.5, 3.5) | 9.5 (9.5, 10.5) |
| 1999–2001 | 7.5 (7.5, ,8.5) | 16.5 (15.5, 18.5) | 10.5 (9.5, 10.5) | 5.5 (5.5, 5.5) | 3.5 (2.5, 3.5) | 10.5 (9.5, 10.5) |
| 2002–2004 | 8.5 (8.5, 9.5) | 17.5 (16.5, 19.5) | 11.5 (10.5, 11.5) | 5.5 (5.5, 6.5) | 3.5 (3.5, 4.5) | 11.5 (10.5, 11.5) |
| 2005–2007 | 9.5 (9.5, 10.5) | 18.5 (17.5, 21.5) | 12.5 (12.5, 13.5) | 6.5 (6.5, 6.5) | 3.5 (2.5, 3.5) | 12.5 (12.5, 13.5) |
| Stratified log-rank testc | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.39 | <0.0001 |
| Cases treated with surgical resection and radiotherapy | ||||||
| 2-year survival, percenta (95% CI) | ||||||
| 1993–1995 | 9 (8, 11) | 29 (23, 36) | 8 (6, 11) | 3 (1, 5) | 0 | 11 (9, 13) |
| 1996–1998 | 11 (9, 13) | 30 (24, 36) | 11 (8, 13) | 3 (2, 5) | 0 | 14 (12, 16) |
| 1999–2001 | 13 (12, 14) | 38 (33, 44) | 13 (11, 15) | 3 (2, 5) | 1 (0, 5) | 17 (15, 18) |
| 2002–2004 | 18 (17, 19) | 39 (35, 44) | 20 (18, 22) | 7 (6, 9) | 5 (2, 10) | 22 (20, 24) |
| 2005–2007 | 24 (22, 26) | 45 (38, 52) | 27 (24, 30) | 14 (11, 17) | 3 (1, 9) | 28 (26, 31) |
| Median survival, monthsb (95% CI) | ||||||
| 1993–1995 | 10.5 (9.5, 10.5) | 15.5 (13.5, 17.5) | 11.5 (10.5, 12.5) | 8.5 (7.5, 8.5) | 7.5 (4.5, 8.5) | 11.5 (11.5, 12.5) |
| 1996–1998 | 10.5 (10.5, 10.5) | 16.5 (14.5, 18.5) | 11.5 (10.5, 12.5) | 7.5 (7.5, 8.5) | 5.5 (4.5, 7.5) | 11.5 (11.5, 12.5) |
| 1999–2001 | 11.5 (10.5, ,11.5) | 19.5 (18.5, 21.5) | 12.5 (12.5, 13.5) | 7.5 (7.5, 8.5) | 5.5 (4.5, 6.5) | 13.5 (12.5, 13.5) |
| 2002–2004 | 12.5 (12.5, 12.5) | 20.5 (18.5, 22.5) | 13.5 (13.5, 14.5) | 8.5 (8.5, 9.5) | 6.5 (5.5, 7.5) | 13.5 (13.5, 14.5) |
| 2005–2007 | 13.5 (13.5, 14.5) | 21.5 (18.5, 26.5) | 15.5 (15.5, 16.5) | 10.5 (9.5, 10.5) | 5.5 (4.5, 6.5) | 16.5 (15.5, 16.5) |
| Stratified log-rank testc | <0.0001 | 0.0003 | <0.0001 | <0.0001 | 0.48 | <0.0001 |
CI, confidence interval
a
Probability of surviving at least 24 completed months (at least 24.5 months, on average)
b
SEER provides follow-up time in number of completed months. Cases who survived at least n months, but fewer than n+1 months, would have n completed months of survival, which corresponds with n.5 months, on average. We therefore added 0.5 months to the result derived from completed months.
c
Stratified by age, sex, race/ethnicity, and marital status