Fig. 7.
4-HNE induced ER stress in 3T3-L1 adipocytes. Mature 3T3-L1 cells were cultured in media with or without 50 or 100 μM 4-HNE at 37°C for up to 4h. (A) Immunoreactive phospho-eIF2α and total eIF2α were detected by western blot. A representative image from 3 independent experiments is shown. (B) CHOP and Grp78 mRNA level in 3T3-L1 adipocytes were measured by RT-PCR and then normalized to 18S mRNA level. n=6. Values represent means ± SEM. Values with different superscripts (A) or asterisks (B) are significantly different from each other, p< 0.05.