Table 1.

Serum was obtained from age P60 mice of indicated genotypes and analyzed for total bilirubin (TB), alkaline phosphatase (ALP), and alanine aminotransferase (ALT). Control mice age P60 without Alb-Cre transgene were used for comparison. Values are listed as mean ± standard error of the mean. IU/L: international units per liter, mg/dL: milligrams per deciliter.

Genotype	n	TB (mg/dL)	n	ALP (IU/L)	n	ALT (IU/L)
Control	15	0.80 ± 0.20	10	22.5 ± 2.6	8	44.0 ± 4.2
HNF-6 KO	9	1.03 ± 0.30	3	12.2 ± 5.7	7	48.2 ± 7.8
RBP KO	4	1.10 ± 0.50	4	14.1 ± 1.6	9	96.1 ± 15.4 **
DKO	33	11.27 ±2.36 **	9	71.5 ± 10.2 **	11	86.8 ± 5.6

P values are calculated using two-tailed Student’s t-test.

^**P<0.01

⁼⁼P<0.0001