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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Child Dev. 2011 Sep 2;84(1):58–75. doi: 10.1111/j.1467-8624.2011.01641.x

Figure 4. Representative examples CpG (cytosine-guanine dinucleotide) sites positively and negatively associated with paternal stress at preschool in girls.

Figure 4

A. A CpG site in the promoter of the TRDN gene (encoding triadin, a possible regulator of calcium release in cardiac and skeletal muscle) was positively associated in girls with paternal stress at preschool ((rho = .55, 13.7% DNA methylation change, slope = .19 (95% CI = .10 – .29), FDR = 0%). No statistically significant association was found in the full group or boys-only analysis.

B. A CpG site in the first exon of the MKRN1 (makorin ring finger protein 1, a ubiquitin E3 ligase with roles in the regulation of telomere length) was negatively associated in girls with paternal stress at preschool (rho = − .54, −5.6% DNA methylation change, slope = −.08 (95% CI = −.12 – −.04), FDR = 0%). No statistically significant association was found in the full group or boys-only analysis. The average beta scale was restricted to show values between 0.5–1.0 (A) or 0 – 0.5 (B) rather than the full range of 0–1.0. Girls are represented as triangles with the regression line being wide-dashed.