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Wnt signaling in mechanotransduction: 1. The Wnt inhibitor sclerostin is secreted from osteocytes and blocks stimulation of lining cells. 2. Deformation due to mechanical loading is perceived by osteocytes, which reduce sclerostin secretion, thus permitting surface cells to be activated by Wnt ligands. 3. Bone apposition reduces deformation and sclerostin secretion is increased again.
