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. Author manuscript; available in PMC: 2012 Feb 24.
Published in final edited form as: Oncogene. 2010 Oct 11;30(8):896–906. doi: 10.1038/onc.2010.470

Figure 7.

Figure 7

BRMS1 overexpression in melanoma cells inhibited blood vessels formation in vivo. (a) Photographs of matrigel plugs excised from mice after 10 days of growth in vivo. (b) The extent of host angiogenesis was examined by immunofluorescent staining for expression of CD31 and BRMS1 in matrigel plugs containing BRMS1-overexpressing or control MMRU cells. Propidium iodide and Hoechst nuclear staining indicated the overall cell density in each matrigel plug. (c) The number for CD31-positive cells was counted from five random fields for both vector control and BRMS1-overexpressing groups. (d) The expression of BRMS1 and IL-6 mRNA was examined in matrigel plugs (n=3/group). **P<0.01; Student’s t-test.