Table 2.
kass (M−1 s−1)a | |||||
---|---|---|---|---|---|
Vivapain-2 | Vivapain-3 | Falcipain-2 | Falcipain-3 | ||
E-64 | 2,31,000 ± 17,700 | 5,690 ± 588 | 14,200 ± 475 | 5,870 ± 428 | |
Z-Phe-Arg-FMK | 47,900 ± 5,090 | 3,680 ± 218 | 2,41,000 ± 20,100 | 60,200 ± 6,740 | |
Mu-Phe-hPhe-FMK | 61,700 ± 6,180 | 540 ± 60 | 2,15,000 ± 5,760 | 5,26,000 ± 59,300 | |
Mu-Leu-hPhe-FMK | 4,50,000 ± 16,800 | 79,200 ± 6,490 | 9,24,000 ± 26,200 | 58,50,000 ± 15,800 | |
Mu-Phe-hPhe-VSph | 267 ± 14 | NAb | 4,890 ± 231 | 2,060 ± 41 | |
Mu-Leu- hPhe-VSph | 88,200 ± 470 | 4,970 ± 370 | 1,02,000 ± 2,530 | 22,000 ± 1,420 | |
Nmetpip-Phe-hPhe-VSPh | 96 ± 5 | 15 ± 004 | 1,230 ± 136 | 1,900 ± 43 | |
Nmetpip-Leu-hPhe-VSPh | 53,600 ± 6,450 | 2,130 ± 158 | 26,300 ± 3,700 | 11,900 ± 762 |
Mu morpholine urea, hPhe homophenylalanine, NmetpipN-methylpiperazine urea, VSPh phenylvinylsulphone
aGeometric mean ± SEM
bNo appreciable activity