Cancellous parameters after 2 weeks of loading, analyzed by microCT from a purely cancellous VOI in the proximal metaphysis. Significant effects of loading were detected only in the Load-Matched group. (A) Bone volume fraction increased 49%, (B) Tissue mineral density (mg/cc) increased 12%, and (C) Trabecular thickness (mm) increased 62%, in loaded limbs of the LM group relative to control limbs. (D) Trabecular separation (mm) decreased 14% due to loading ([LM + SM loaded limbs] vs [LM + SM control limbs]). Data are represented as mean + SD.
a-bgroups with different letters are significantly different p<0.05 by linear-mixed model with repeated measures followed by means comparisons with Bonferroni correction. cp<0.05 main effect of loading.