Table 6.
Top 10 drug target candidates ranked based on criteria such as high eigenvector (influential) and closeness (central) values, previous identification as a possible target, and essentiality.
| UniProt Acc | Gene name | Functional class | Network centrality scores | Previous identification sources | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Eigen | Betweenness | Closeness | Degree | TDR | UniProt | Drugome [36] | Essential [37] | |||
| Q7D6Z3 | MT2600 | Lipid metabolism | 0.08369 | 128207.32 | 0.37 | 207 | Yes | Yes | ||
| P0A5Y6 | inhA | Lipid metabolism | 0.08216 | 27379.65 | 0.36 | 162 | Yes | Yes | Yes | |
| O06934 | glf | Cell wall and cell processes | 0.08152 | 67825.15 | 0.36 | 172 | Yes | |||
| Q11141 | proC | Intermediary metabolism and respiration | 0.08123 | 57376.99 | 0.36 | 165 | Yes | Yes | ||
| P63562 | argC | Intermediary metabolism and respiration | 0.08119 | 51684.48 | 0.36 | 163 | Yes | Yes | ||
| P63629 | hom | Intermediary metabolism and respiration | 0.08137 | 50079.08 | 0.36 | 171 | Yes | Yes | ||
| P64328 | hemA | Intermediary metabolism and respiration | 0.08126 | 77831.05 | 0.36 | 173 | Yes | Yes | ||
| P0A544 | serA | Intermediary metabolism and respiration | 0.08133 | 28205.61 | 0.36 | 164 | Yes | Yes | ||
| P66783 | Rv3791 | Intermediary metabolism and respiration | 0.08162 | 27347.66 | 0.35 | 157 | Yes | Yes | ||
| O33290 | ftsK | Cell wall and cell processes | 0.00172 | 62658.74 | 0.35 | 97 | Yes | Yes | ||