Figure 3.

Promoter region (+39 to −1143 bp) of the human LTF gene and transcription boxes: (a) M y b ¹, S P1², C/E B P ³, E T s ⁴, and S P1⁵ (region –35 to –85) are involved in LTF expression during myeloid differentiation [82]. (b) E R E ⁶, C O U P ⁷, and G A T A-1⁸ (region –340 to –372), a highly conserved estrogen response element (ERE) overlapping with a chicken ovalbumin upstream promoter (COUP) element [83]. (c) S F R E ⁹  and C O U P ¹⁰ (region – 377 to –394), an extended estrogen response element half site in addition to the ERE, which renders the human LTF gene extremely responsive to estrogen stimulation [83]. (d) T A A C C ¹¹, a highly conserved silencing factor (–774 to –778) that binds the CCAAT displacement protein (CDP/cut) [84].