. Author manuscript; available in PMC: 2011 Dec 11.

Published in final edited form as: Biol Psychiatry. 2010 Jan 15;67(10):965–973. doi: 10.1016/j.biopsych.2009.11.026

Table 2.

Group Comparisons for Global, Cortical, and Subcortical Brain Volumes

Region	Control Mean ± SE	Influenza Mean ± SE	Brain Vol. Difference, %	p Uncorrected	p ICV-Corrected
Total Brain (ICV)	93,862 ± 2,275	89,744 ± 1744	4.4	.086	NA
Total GM	53,913 ± 1233	50,915 ± 945	5.6	.028^a	.091
Total WM	21,620 ± 573	20,842 ± 440	3.6	.170	.573
Total CSF	18,329 ± 681	17,988 ± 522	1.9	.631	.261
Total Subcortical	8,714 ± 182	8,431 ± 139	3.2	.129	.294
Cortical
GM	40,939 ± 1,042	38,413 ± 799	6.2	.029^a	.031^a
WM	15,092 ± 435	14,307 ± 333	5.2	.091	.466
Lateral Ventricles	603 ± 62	645 ± 47	−7.0	.596	.283
Cerebellum				.376	.172
GM	4,425 ± 123	4,374 ± 94	1.2	.372	.416
WM	2,163 ± 57	2,152 ± 44	.5	.622	.038^a

Significant group differences are shown with and without correcting for intracranial volumes (ICV) (brain region divided by ICV). Data are presented as raw means (mm³) ± SE. Positive values for the percent difference in brain volume indicate greater volumes in control animals. Control n = 7, Influenza n = 12.

GM, gray matter; WM, white matter; CSF, cerebrospinal fluid.

p values below .05.