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Schema depicting differential mechanisms of Ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats. AT1R expression was similar in aortae from adult and aged rats whereas there was upregulation of AT2R, MasR, and ACE2. Therefore, a lower level of AT1R blockade with candesartan (X) was required in aged animals (b) compared with adult animals (a) in order to unmask the vasodilator axis. MasR was not functionally active in adult rats.
