Table 2.

Cytogenetic molecular classification of adult ALL based on more recently published data.

Risk group	Chromosomal/molecular aberrations	5y-DFS	5y-OS
STANDARD-RISK	Isolated 9p/p15-p16 deletions High hyperdiploidy Normal karyotype/no molecular aberrations	35–68%	48–80%
INTERMEDIATE-RISK	del(6q) Trisomy of chromosome 21 Trisomy of chromosome 8 t(1;19)/E2A-PBX	37–51%	35–40%
HIGH-RISK	t(9;22)/BCR-ABL t(4;11)/MLL-AF4 11q23 MLL rearrangements Monosomy of chromosome 7 Low hypodiploidy/near triploidy Complex karyotype High BAALC expression Aberrations of IKZF1 gene	10–52%	15–35%

CR: complete remission; 5y-DFS: 5 years disease-free survival; 5y-OS: 5 years overall survival.