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Time course study showing fibronectin (FN)–SiRNA efficacy. Relative levels of FN protein in rat retinas at different time points (3 days–6 weeks) after intravitreal injection of 3 μM FN–siRNA. By the 1-week time point, retinal FN protein expression was significantly reduced and remained inhibited at the 6-week time point. Scrambled siRNA showed no effect on the FN protein level. *=p<0.05 versus “0 days” group mean; n=4/group.
