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. 2011 Dec 6;17:3166–3174.

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Copyright © 2011 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Development of acellular capillaries in the diabetic retina. A-D: Representative retinal trypsin digest (RTD) images showing the effect of fibronectin (FN)-siRNA on the development of acellular capillaries (as indicated by arrows) in retinas of a (A) normal rat, (B) diabetic rat, (C) diabetic rat intravitreally injected with FN-siRNA, and (D) diabetic rat intravitreally injected with scrambled siRNA. FN-siRNA treatment in the diabetic rats specifically reduced the development of acellular capillaries compared to those of uninjected diabetic rats. E: Graphical representation of acellular capillaries in four groups of rats: normal, diabetic, diabetic injected with FN-siRNA, and diabetic injected with scrambled siRNA, showing that an intravitreal injection of FN-siRNA reduces the development of acellular capillaries in diabetic rat retinas. Normal versus Diabetic *=p<0.05; Diabetic versus Diabetic+FN-siRNA **=p<0.05, n=8.