Figure 1.

(a) SCA plot showing the hit distribution for the H₄R (Red), the 5-HT_3AR (blue), the 5-HT_3AR and H₄R (green) as well as inactives, compounds which do not bind H₄R or 5HT_3AR (grey). Hits presented in Table 1 are labeled by their corresponding number. (b) Schematic representation of the overlap between H₄R and 5-HT_3AR ligands. (c) Distribution of the complexity of H₄R selective fragments (red line), 5-HT_3AR selective fragments (blue line), dual H₄R/5-HT_3AR fragments (green line), and inactives (dotted grey line).