Table 4.
Neuropathological diagnoses of dementia in post-stroke survivors
| Variable | Post-stroke no dementia | Incident dementia | Dementia at baseline | P-values* |
|---|---|---|---|---|
| No of cases | 27 | 23 | 6 | – |
| Age | 84 ± 4 | 88 ± 5 | 85 ± 8 | P = 0.009 PSND versus ID |
| Gender | 15M/12F | 12M/11F | 3M/3F | – |
| CAMCOG (highest) | 92 ± 6 | 82 ± 9 | 58 ± 11 | P = 0.000 PSND versus ID; versus DBaseline |
| CAMCOG (last) | 89 ± 6 | 59 ± 23 | 31 ± 33 | P = 0.000 PSND versus ID; versus DBaseline |
| CDR | 0.1 ± 0.4 | 1.4 ± 0.9 | 3.0 ± 0 | P = 0.000 PSND versus ID; versus DBaseline |
| Duration of survival (days from baseline stroke to death) | 1606 ± 857 | 1304 ± 811 | nd | P > 0.05 |
| Brain weight | 1267 ± 118 | 1229 ± 152 | 1219 ± 69 | P > 0.05 |
| Number of infarcts | 3.9 ± 2.0 | 4.5 ± 2.8 | 6.2 ± 3.9 | P > 0.05 |
| Microinfarction (>three lesions in four regions) | 41% | 50% | 50% | P = 0.05 PSND versus ID |
| CERAD score | 1.3 ± 0.7 | 0.9 ± 0.9 | 1.7 ± 1.5 | P > 0.05 |
| Braak staging | 2.5 ± 1.3 | 2.6 ± 1.1 | 3.7 ± 2.6 | P > 0.05 |
| Neurodegenerative pathology (at least one type) | 30% | 48% | 50% | P = 0.05 PSND versus ID |
| Diagnosis | PSND (n = 27) | Vascular dementia (n = 18); mixed: ATP with cerebrovascular disease (n = 2), LBP (n = 1), FTLD (n = 1), or PSP (n = 1) | Vascular dementia (n = 3); mixed Alzheimer's disease with cerebrovascular disease (n = 3) |
Values are mean ± SD, unless noted otherwise.
ATP = Alzheimer type pathology; CDR = clinical dementia rating; DBaseline = dementia at baseline; FTLD = frontotemporal lobar degeneration; ID = incident dementia; LBP = Lewy body pathology; n = number of autopsied subjects (total n = 56); nd = not defined; PSND = post-stroke no dementia; PSP = progressive supranuclear palsy.
Mixed = vascular and neurodegenerative pathology.
There were no differences in the distribution of apolipoprotein E genotypes with the demented versus non-demented groups.
*P-values for two independent samples, Mann–Whitney U test or Chi-square analysis.