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. 2011 Nov 25;134(12):3490–3498. doi: 10.1093/brain/awr289

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© The Author (2011). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Linkage analysis of Families A and B mapped the PKD to a region on chromosome 16p12.1-q12.1. The partial pedigrees of Families A and B were shown and haplotype analysis was indicated on chromosome 16 using 11 markers. The haplotype assumed to carry the disease allele is indicated with black bars. The haplotype with recombination event is indicated with black and white bars. Subjects in Families A and B are identified by the Arabic numerals above the symbol; and the Roman numerals denote the generations. Open symbols = unaffected; filled symbols = affected; symbols with a diagonal line = deceased subjects; squares = male; circles = female; arrow = the proband; minus = wild-type allele; plus = mutant allele; NG = not genotyped.