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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Endocr Relat Cancer. 2011 Sep 20;18(5):R183–R196. doi: 10.1530/ERC-11-0141

Figure 4.

Figure 4

Alternatively spliced AR isoforms identified in prostate cancer (PCa). (A) Schematic of the AR gene locus with locations of alternatively spliced, cryptic exons illustrated in red. The location of an intragenic tandem duplication identified in 22Rv1 cells is indicated. (B) Alternative splicing of cryptic exons in the AR locus or exon skipping gives rise to COOH-terminally truncated AR mRNA isoforms that encode constitutively active, ligand-independent transcription factors. CE2’ denotes the use of an alternative splice acceptor site for splicing of exon CE2 downstream from exon 3. Additional alternatively-spliced mRNA isoforms which have not been cloned or characterized are not illustrated in this figure, but are discussed in the text.