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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Adv Pharmacol. 2011;62:109–141. doi: 10.1016/B978-0-12-385952-5.00008-7

Figure 2.

Figure 2

Location of the inactivating mutations in the human GnRHR. Black ovals are mutations that provoke complete loss-of-function of the receptor, whereas grey ovals are mutations that lead to partial loss-of-function. Also shown is the location of Lys191 at the second extracellular loop (hatched circle) and the sequence of the COOH-terminus of the catfish GnRHR (grey-shaded circles), which is a targetting sequence employed in vitro to promote trafficking of GnRHRs to the plasma membrane. EC, extracellular space; IC, intracellular space.