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. Author manuscript; available in PMC: 2011 Dec 12.
Published in final edited form as: Sci Transl Med. 2010 Nov 10;2(57):57ra82. doi: 10.1126/scitranslmed.3001510

Figure 1. Clinical Features of Patients with Rapid and Slowly Progressive Forms of IPF and TLR9 Expression.

Figure 1

A. The survival of IPF patients classified as rapid (red line) or slow progressors (black line). B. Representative histology of IPF in a patient with slow (a,b) and rapid (c,d) progression shown at 20× and 400× magnification. C. Quantitative TaqMan PCR analysis of TLR9 gene expression in upper lobe SLBs from rapid and slow progressors. The data shown are the mean of all the combined upper lobe mRNA values compared to the mean of normal SLBs mRNA values (standardized to GAPDH housekeeping gene). The error bar shows the SEM of all the data in the rapid (n=10) and stable (n=13) progressor patient groups. The two-tailed P value was determined by the unpaired t test with Welch correction. D. Representative immunohistochemical staining of TLR9 in SLBs from a total of 7 slow (a) and 5 rapid (c) progressors shown at 20× magnification. Corresponding fields stained with isotype control (IgG) shown in b and d.