Figure 3.

Differences in Kir2 channel current amplitude and whole-cell capacitance between D₁ and D₂ MSNs. a, Sample voltage-clamp recording of a spiny neuron, with a focus on the inwardly rectifying Kir2 current present during a voltage ramp. b, Mean current–voltage relationships of D₁ (red) and D₂ (blue) MSNs as measured with a 200 ms ramp, displayed with shaded SEM. Note the divergence of the two populations, with a difference current (inset) mirroring the Kir2 current rectification and reversal profile. Arrow indicates E_K. c, Overlapping, yet significantly different, Gaussian distributions of whole-cell capacitance measurements taken from D₁ and D₂ MSNs (D₁ MSN: median, 192 pF, n = 28; D₂ MSN: median, 157 pF, n = 30; p < 0.05). d, Peak Kir2/K leak channel conductance (measured with −150 mV step; see arrow in a) is positively correlated to whole-cell capacitance in D₁ and D₂ MSNs.