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Substrate Scope for C–H Functionalization
| entry | substrate | product | yieldb |
|---|---|---|---|
| 1 |
 5 |
 6 |
92%c |
| 2 |
 7 |
 8 |
68%d,e |
 8a |
20% | ||
| 3 |
 9 |
 10 |
60% |
| 4 |
 11 |
 12 |
61% |
| 5 |
 13 |
 14 |
53% |
| 6 |
 15 |
 16 |
57% |
| 7 |
 17 |
 18 |
56% |
| 8 |
 19 |
 20 |
51% |
| 9 |
 21 |
 22 |
46% |
Reaction Conditions: Pd(OAc)2 (10 mol %), PhI(OAc)2 (2.0 equiv), CH3CN, rt, 12 h;
Isolated yield (%) after purification by chromatography on SiO2;
dr 1.75:1;
dr 1.3:1;
see ref 21
