Table 4.
Selected clinical trials using dendritic cells (DCs).
| Reference | Patients | Immunologic response | Clinical response |
|---|---|---|---|
| [155] |
n = 7 (GBM: 6, AA: 1) |
Cytotixic and memory T cells found in recurrent tumor bulk | Median survival: 455 days (Control group: 257 days) |
| [156] |
n = 12 (GBM: 7, Recurrent GBM: 5) |
Cytotoxicity against autologous tumor cells. Cytotoxic T cells found in recurrent tumor bulk. | Median TTP: 19.9 mo (P = 0.028), Median survival: 35.8 mo (P = 0.006) |
| [157] |
n = 18 EGFRvIII expressing GBM |
82% of recurrent tumors lost EGFRvIII expression | Median survival: 26 mo (P = 0.001) |
| Others: [80, 84, 158–173] |