Table 2.
Thyroid hormones according to gestational age, Rhea mother-child cohort, Crete, Greece.
| N | Distribution | 2.5th percentiles | 97.5th percentile | Median | Mean | SD | Reference range | |
|---|---|---|---|---|---|---|---|---|
| 1st trimester | ||||||||
| TSHa μIU/mL | 141 | Not normal | 0.05 | 2.53 | 1.02 | 1.08 | 0.61 | 0.05–2.53 |
| free T3b pg/mL (pmol/L) | 141 | Normald | 1.84 (2.83) | 5.39 (8.28) | 3.21 (4.93) | 3.38 (5.19) | 0.94 (1.44) | 1.54–5.22 (2.37–8.02) |
| free T4c ng/dL (pmol/L) | 139 | Normale | 0.96 (12.36) | 1.60 (20.59) | 1.24 (15.96) | 1.24 (15.96) | 0.15 (1.93) | 0.95–1.53 (12.23–19.69) |
|
| ||||||||
| 2nd trimester | ||||||||
| TSHa μIU/mL | 257 | Not normal | 0.18 | 2.73 | 1.14 | 1.23 | 0.65 | 0.18–2.73 |
| free T3b pg/mL (pmol/L) | 256 | Normal | 1.99 (3.06) | 5.30 (8.14) | 3.52 (5.41) | 3.55 (5.45) | 0.87 (1.34) | 1.78–5.29 (2.73–8.13) |
| free T4c ng/dL (pmol/L) | 258 | Normal | 0.84 (10.81) | 1.44 (18.53) | 1.16 (14.93) | 1.16 (14.93) | 0.15 (1.93) | 0.87–1.45 (11.20–18.66) |
TSH: thyroid-stimulating hormone; free T3: free triiodothyronine; free T4: free thyroxine.
aDifference between first and second trimester: P = 0.058.
bDifference between first and second trimester: P = 0.054.
cDifference between first and second trimester: P < 0.001.
dAfter outlier deletion and log transformation.
eAfter outlier deletion.